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YOU ARE HERE:  Browse Product Catalog > Crosslinking and Protein Modification > Crosslinking Reagents > Bioconjugate Toolkit Reagents  


Bioconjugate Toolkit Reagents 

An innovative crosslinking system for controlled, two-step bioconjugation.

Thermo Scientific Bioconjugate Toolkit Reagents provide biomolecule conjugation chemistry that is easy to use and applicable to almost any conjugation scheme. These reagents are heterobifunctional, containing an N-hydroxysuccinimde ester (NHS-ester) and either a hydrazine /hydrazide or an aldehyde group. Biomolecules are first reacted with the NHS ester to form a stable amide bond, followed by subsequent binding to an aldehyde-modified molecule to form a conjugate. This conjugate does not require harsh reducing agents (such as sodium cyanoborohydride) in order to stabilize the conjugate. Conjugates produced utilizing these crosslinkers have extended stabilities in aqueous solution. Figure 1 is a reaction scheme for producing bioconjugates using these new crosslinking reagents.


Bioconjugate ToolKit Scheme

Feature Benefit
Long-term stability Modified biomolecules or surfaces can be prepared, stored and used when needed. Hydrazine (SANH)-reactive moieties are stable for several months. Hydrazide (SHTH)- and aldehyde-reactive moieties are stable indefinitely.
Applicable to most conjugation schemes   Can be used to prepare a bioconjugate or to modify a surface
Easy to use Reactions occur in an aqueous environment, no hazardous reducing agents required


Bioconjugate ToolKit Figure Bioconjugate ToolKit Figure
Bioconjugate ToolKit Figure Bioconjugate ToolKit Figure
Bioconjugate ToolKit Figure

Ordering Information
Certificate of AnalysisCertificate of Analysis   Product InstructionsProduct Instructions   MSDSMSDS
Buy Product # Description Pkg. Size Files Price
Add 22400 SANH (succinimidyl 4-hydrazinonicotinate acetone hydrazone) 10 mg Product Instructions MSDS for product # 22400 SANH (succinimidyl 4-hydrazinonicotinate acetone hydrazone) $248.00
Add 22405 C6-SANH (C6-succinimidyl 4-hydrazinonicotinate acetone hydrazone) 10 mg Product Instructions MSDS for product # 22405 C6-SANH (C6-succinimidyl 4-hydrazinonicotinate acetone hydrazone) $330.00
Add 22411 SHTH (succinimidyl 4-hydrazidoterephthalate hydrochloride) 10 mg Product Instructions MSDS for product # 22411 SHTH (succinimidyl 4-hydrazidoterephthalate hydrochloride) $248.00
Add 22419 SFB (succinimidyl 4-formylbenzoate) 25 mg Product Instructions MSDS for product # 22419 SFB (succinimidyl 4-formylbenzoate) $165.00
Add 22423 C6-SFB (C6-succinimidyl 4-formylbenzoate) 25 mg Product Instructions MSDS for product # 22423 C6-SFB (C6-succinimidyl 4-formylbenzoate) $217.00

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