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An innovative crosslinking system for controlled, two-step bioconjugation.
Thermo Scientific Bioconjugate Toolkit Reagents provide biomolecule conjugation chemistry that is easy to use and applicable to almost any conjugation scheme. These reagents are heterobifunctional, containing an N-hydroxysuccinimde ester (NHS-ester) and either a hydrazine /hydrazide or an aldehyde group. Biomolecules are first reacted with the NHS ester to form a stable amide bond, followed by subsequent binding to an aldehyde-modified molecule to form a conjugate. This conjugate does not require harsh reducing agents (such as sodium cyanoborohydride) in order to stabilize the conjugate. Conjugates produced utilizing these crosslinkers have extended stabilities in aqueous solution. Figure 1 is a reaction scheme for producing bioconjugates using these new crosslinking reagents.
| Feature |
Benefit |
| Long-term stability |
Modified biomolecules or surfaces can be prepared, stored and used when needed. Hydrazine (SANH)-reactive moieties are stable for several months. Hydrazide (SHTH)- and aldehyde-reactive moieties are stable indefinitely. |
| Applicable to most conjugation schemes |
Can be used to prepare a bioconjugate or to modify a surface |
| Easy to use |
Reactions occur in an aqueous environment, no hazardous reducing agents required |
Ordering Information
|
 Bulk quantities: Inquire  Certificate
of Analysis  Product
Instructions  MSDS |
| Product # |
Description |
Pkg. Size |
Files |
Price |
| 22400 |
SANH (succinimidyl 4-hydrazinonicotinate acetone hydrazone) |
10 mg |
|
$248.00
|
| 22405 |
C6-SANH (C6-succinimidyl 4-hydrazinonicotinate acetone hydrazone) |
10 mg |
|
$330.00
|
| 22411 |
SHTH (succinimidyl 4-hydrazidoterephthalate hydrochloride) |
10 mg |
|
$248.00
|
| 22419 |
SFB (succinimidyl 4-formylbenzoate) |
25 mg |
|
$165.00
|
| 22423 |
C6-SFB (C6-succinimidyl 4-formylbenzoate) |
25 mg |
|
$217.00
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