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CHAPS & CHAPSO  |
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Zwitterionic detergents that protect the native state of proteins.
Applications
- Solubilizing the opiate receptor from rat brain cell membranes, while retaining the reversible opiate binding property of the receptor1
- Purifying microsomal signal peptidase as a complex2
- Solubilizing dopamine D2,3, muscarinic4, and opiate receptors5 from brain tissue
Highlights
- Able to disrupt nonspecific protein interactions
- Less protein aggregation than nonionic detergents
- Electrically neutral and nondenaturing
- Easily removed by dialysis
References
- Simonds, W.F., et al. (1980). Proc. Natl. Acad. Sci. (USA) 77, 4623-4627.
- Evans, E.A., et al. (1986). Proc. Natl. Acad. Sci. (USA) 83, 581-585.
- Kuno, T., et al. (1984). J. Neurochem. 41, 841.
- Kuno, T., et al. (1983). BBRC 112, 948.
- Chow, T., et al. (1983). Mol. Pharmacol. 24, 203.
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Certificate of Analysis
Product Instructions
MSDS