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Kits and crosslinker systems for specialized crosslinking strategies, including photoreactive amino acids for metabolic labeling, Staudinger reagents for chemoselective ligation, and biotin label transfer compounds for protein interaction experiments. |
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Homobifunctional amine-specific protein crosslinking reagents based on NHS-ester and imidoester reactive groups for selective conjugation of primary amines; available in short, long, cleavable, irreversible, membrane permeable and cell surface varieties. |
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Heterobifunctional protein crosslinking reagents for conjugation between primary amine (lysine) and sulfhydryl (cysteine) groups of proteins and other molecules; available with different lengths and types of spacer arms. |
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Carbodiimide crosslinking reagents DCC and EDC (EDAC) for conjugation of carboxyl groups (glutamate, aspartate, C-termini) to primary amines (lysine, N-termini); also N-hydroxysuccinimide (NHS) for stable activation of carboxylates for amine-conjugation. |
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Aryl azide, diazirine and other photo-reactive (light-activated) chemical crosslinking reagents to conjugate proteins, nucleic acids and other molecular structures involved in receptor-ligand interaction complexes via two-step activation. |
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Crosslinking reagents based on maleimide and hydrazide reactive groups for conjugation and formation of covalent crosslinks between sulfhydryl (cysteine) and aldehyde (oxidized glycoprotein carbohydrate) groups. |
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Crosslinking reagents based on maleimide and isocyanate reactive groups for conjugation and formation of covalent crosslinks between sulfhydryl and hydroxyl groups. |
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Sulfhydryl-specific crosslinking reagents based on maleimide or pyridyldithiol reactive groups for selective covalent conjugation of protein and peptide thiols (reduced cysteines) to form stable thioether bonds. |
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