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TSAT (Tris-succinimidyl aminotriacetate)


For three-way crosslinking between primary amine molecules.

Pierce TSAT

Thermo Scientific Pierce TSAT is tris-(succinimidyl) aminotriacetate, a novel trifunctional crosslinker that contains three short spacers arms linked to a central nitrogen atom, each ending in an amine-reactive NHS-ester group.

Highlights:

  • Reactive groups: NHS ester (three ends)
  • Reactive towards: amino groups (primary amines)
  • NHS ester couples to amines at pH 7-9 form stable amide bonds
  • Trifunctional amine-reactive crosslinking agent
  • Non-cleavable
  • Water-insoluble (dissolve first in DMF or DMSO)

Applications:

  • Preparation of multicomponent aggregates
  • Polyerization of protein interactions for nearest-neighbor studies
  • Core molecule for the construction of dendritic polymers

Product Details:

Tris-succinimidyl aminotriacetate; TSAT
 
Chemical structure of TSAT crosslinking reagent.

Product References:

Crosslinker Application Guide -- search for recent literature references for this product

Related Resources:

Overview of crosslinking
Chemistry of crosslinking

Related Products:

Crosslinkers at a glance (selection guide)
TMEA (trifunctional sulfhydryl-reactive crosslinker)


Ordering Information
 
Product # Description Pkg. Size Instructions MSDS CofA Price
33063 TSAT
Formulation: Tris-succinimidyl aminotriacetate; solid
Sufficient For: 104mL of typical 1X (1mM) reaction solution, or approx. 25 uses at 2mg reagent per use
50mg Product Instructions for product #33063 TSAT MSDS for product #33063 TSAT Certificate of Analysis for product #33063 TSAT $139.00

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Instructions | MSDS | CofA
Product Instructions | MSDS | CofA  

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