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For three-way crosslinking between sulfhydryl molecules.

Pierce TMEA

Thermo Scientific Pierce TMEA is a trifunctional crosslinker containing three reactive maleimide groups to enable three-way conjugation and polymerization of sulfhydryl-containing molecules.


  • Reactive groups: maleimide (both ends)
  • Reactive towards: sulfhydryl groups
  • 3-way, sulfhydryl-to-sulfhydryl crosslinker; tris (2-maleimidoethyl) amine, composed of three maleimide groups on short spacer arms
  • Water-insoluble – dissolve first in DMF or DMSO, then add to aqueous reaction buffers
  • Noncleavable
  • Useful for the preparation of trimeric complexes of cysteine-containing peptides and other thiol-containing compounds
  • Core molecule for the construction of dendritic polymers

Product Details:

Tris(2-maleimidoethyl)amine; TMEA
Chemical structure of TMEA crosslinking reagent.

Product References:

Crosslinker Application Guide -- search for recent literature references for this product

Related Resources:

Overview of crosslinking
Chemistry of crosslinking

Related Products:

Crosslinkers at a glance (selection guide)
TSAT (trifunctional amine-reactive crosslinker)

Ordering Information
Product # Description Pkg. Size Instructions MSDS CofA Price
33043 TMEA
Formulation: Tris(2-maleimidoethyl)amine; solid
Sufficient For: 647mL of typical 1X (0.2mM) reaction solution, or approx. 25 uses at 2mg reagent per use
50mg Product Instructions for product #33043 TMEA MSDS for product #33043 TMEA Certificate of Analysis for product #33043 TMEA $192.00

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Instructions | MSDS | CofA
Product Instructions | MSDS | CofA  

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