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A water-soluble amine-to-sulfhydryl crosslinker with a medium-length aromatic spacer arm (11.6 angstroms).

Pierce Sulfo-SMPB

Thermo Scientific Pierce Sulfo-SMPB is a water-soluble amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a medium-length aromatic spacer arm (11.6 angstroms).


  • Reactive groups: sulfo-NHS ester and maleimide
  • Reactive towards: amino and sulfhydryl groups
  • Extended chain length limits steric hindrance
  • Non-cleavable
  • Water-soluble (compare to SMPB)
  • Membrane impermeable, allowing for cell surface labeling

Product Details:

Chemical structure of Sulfo-SMPB crosslinking reagent.


  1. Iwai, K., Fukuoka, S.-I., Fushiki, T., Kido, K., Sengoku, Y. and Semba, T. (1988). Preparation of a verifiable peptide-protein immunogen: direction-controlled conjugation of a synthetic fragment of the monitor peptide with myoglobin and application for sequence analysis. Anal. Biochem. 171, 277-282.
  2. Teale, J.M. and Kearney, J.R. (1986). Clonotypic analysis of the fetal B cell repertoire: Evidence for an early and predominant expression of idiotypes associated with the VH 36-60 family. J. Mol. Cell. Immunol. 2, 283-292.

Product References:

Crosslinker Application Guide -- search for recent literature references for this product

Related Resources:

Overview of crosslinking
Chemistry of crosslinking

Related Products:

Crosslinkers at a glance (selection guide)

Ordering Information
Product # Description Pkg. Size Instructions MSDS CofA Price
22317 Sulfo-SMPB 50mg Product Instructions for product #22317 Sulfo-SMPB MSDS for product #22317 Sulfo-SMPB Certificate of Analysis for product #22317 Sulfo-SMPB $185.00

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Instructions | MSDS | CofA
Product Instructions | MSDS | CofA  

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