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A water-soluble amine-to-sulfhydryl crosslinker with a long spacer arm (16.3 angstroms).

Pierce Sulfo-KMUS

Thermo Scientific Pierce Sulfo-KMUS is a water-soluble amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a long spacer arm (16.3 angstroms).


  • Reactive groups: sulfo-NHS ester and maleimide
  • Reactive toward: amino and sulfhydryl groups
  • Long aliphatic spacer arm compared to Sulfo-GMBS
  • Sulfo-NHS ester reacts with primary amines at pH 7-9, forming a stable amide bond
  • Maleimide reacts with -SH groups at pH 6.5-7.5, forming a stable thioether bond
  • Non-cleavable
  • Water-soluble

Product Details:

N-kappa-Maleimidoundecanoyl-oxysulfosuccinimide ester; Sulfo-KMUS
Chemical structure of Sulfo-KMUS crosslinking reagent.


  1. Fujiwara, K., et al. (1988). Sandwich enzyme immunoassay of tumor-associa- ted antigen sialosylated Lewis (x) using β-D-galactosidase coupled to a monoclonal antibody of IgM isotype. J. Immunol. Methods. 112, 77-83.

Product References:

Crosslinker Application Guide -- search for recent literature references for this product

Related Resources:

Overview of crosslinking
Chemistry of crosslinking

Related Products:

Crosslinkers at a glance (selection guide)

Ordering Information
Product # Description Pkg. Size Instructions MSDS CofA Price
21111 Sulfo-KMUS
Formulation: N-kappa-Maleimidoundecanoyl-oxysulfosuccinimide ester; solid
Sufficient For: 104mL of typical 1X (1mM) reaction solution, or approx. 25 uses at 2mg reagent per use
50mg Product Instructions for product #21111 Sulfo-KMUS MSDS for product #21111 Sulfo-KMUS Certificate of Analysis for product #21111 Sulfo-KMUS $282.00

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Instructions | MSDS | CofA
Product Instructions | MSDS | CofA  

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