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Sulfo-GMBS


A water-soluble amine-to-sulfhydryl crosslinker with a short spacer arm (7.3 angstroms).

Pierce Sulfo-GMBS

Thermo Scientific Pierce Sulfo-GMBS is a water-soluble amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a short spacer arm (7.3 angstroms).

Highlights:

  • Reactive groups: sulfo-NHS ester and maleimide
  • Reactive towards: amino and sulfhydryl groups
  • Non-cleavable
  • Water-soluble (compare to GMBS)
  • Has a low potential for illiciting crosslinker immune response, ensuring that the primary response to the antigen-carrier protein conjugate is not diluted by a response against a determinant on the crosslinker
  • GMBS and Sulfo-GMBS are reported to be less immunogenic than SMCC

Product Details:

N-gamma-Maleimidobutyryl-oxysulfosuccinimide ester; Sulfo-GMBS
 
Chemical structure of Sulfo-GMBS crosslinking reagent.

References:

  1. Fujiwara, K., et al. (1988). Sandwich enzyme immunoassay of tumor-associated antigen sialosylated Lewis (x) using β-D-galactosidase coupled to a monoclonal antibody of IgM isotype. J. Immunol. Meth. 112, 77-83.

Product References:

Crosslinker Application Guide -- search for recent literature references for this product

Related Resources:

Overview of crosslinking
Chemistry of crosslinking

Related Products:

Crosslinkers at a glance (selection guide)


Ordering Information
 
Product # Description Pkg. Size Instructions MSDS CofA Price
22324 Sulfo-GMBS
Formulation: N-gamma-Maleimidobutyryl-oxysulfosuccinimide ester; powder solid
Sufficient For: 131mL of typical 1X (1mM) reaction solution, or approx. 25 uses at 2mg reagent per use
50mg Product Instructions for product #22324 Sulfo-GMBS MSDS for product #22324 Sulfo-GMBS Certificate of Analysis for product #22324 Sulfo-GMBS $202.00

Add to cart
22324B Sulfo-GMBS
Formulation: N-gamma-Maleimidobutyryl-oxysulfosuccinimide ester; powder solid
Custom MSDS for product #22324B Sulfo-GMBS Certificate of Analysis for product #22324B Sulfo-GMBS

Instructions | MSDS | CofA
Product Instructions | MSDS | CofA  

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