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SMPT


A long-chain disulfide crosslinker for strong yet reversible amine-to-sulfhydryl conjugation.

Pierce SMPT

Thermo Scientific Pierce SMPT is a long-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form strong (hindered) yet cleavable (reducible) disulfide bonds with cysteine sulfhydryls.

Highlights:

  • Reactive groups: NHS ester and pyridyldithiol
  • Reactive towards: amino and sulfhydryl groups
  • Cleavable with disulfide reducing agents
  • Water-insoluble (dissolve first in DMF or DMSO)
  • Contains a hindered disulfide bond; has formed immunotoxins with improved stability
  • In vitro, an SMPT conjugate was as effective as conjugates formed with SPDP and 2-IT
  • Compare to other varieties of SPDP-type reagents, including pegylated forms

Product Details:

 4-Succinimidyloxycarbonyl-alpha-methyl-alpha(2-pyridyldithio)toluene; SMPT
 
Chemical structure of SMPT crosslinking reagent.

Product References:

Crosslinker Application Guide -- search for recent literature references for this product

Related Resources:

Overview of crosslinking
Chemistry of crosslinking

Related Products:

Crosslinkers at a glance (selection guide)
Other SPDP-type Reagents


Ordering Information
 
Product # Description Pkg. Size Instructions MSDS CofA Price
21558 SMPT
Formulation: 4-Succinimidyloxycarbonyl-alpha-methyl-alpha(2-pyridyldithio)toluene; powder solid
Sufficient For: 129mL of typical 1X (1mM) reaction solution, or approx. 25 uses at 2mg reagent per use
50mg Product Instructions for product #21558 SMPT MSDS for product #21558 SMPT Certificate of Analysis for product #21558 SMPT $240.00

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Instructions | MSDS | CofA
Product Instructions | MSDS | CofA  

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