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An amine-to-sulfhydryl crosslinker with a medium-length aromatic spacer arm (11.6 angstroms).

Pierce SMPB

Thermo Scientific Pierce SMPB is an amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a medium-length aromatic spacer arm (11.6 angstroms).


  • Reactive groups: NHS ester and maleimide
  • Reactive towards: amino and sulfhydryl groups
  • Extended chain analog of MBS
  • Non-cleavable
  • Water-insoluble (dissolve first in DMF or DMSO)
  • Conjugates formed with SMPB are more stable in serum than SPDP conjugates

Product Details:

Succinimidyl 4-(p-maleimidophenyl)butyrate; SMPB
Chemical structure of SMPB crosslinking reagent.

Product References:

Crosslinker Application Guide -- search for recent literature references for this product

Related Resources:

Overview of crosslinking
Chemistry of crosslinking

Related Products:

Crosslinkers at a glance (selection guide)

Ordering Information
Product # Description Pkg. Size Instructions MSDS CofA Price
22416 SMPB
Formulation: Succinimidyl 4-(p-maleimidophenyl)butyrate; powder solid
Sufficient For: 140mL of typical 1X (1mM) reaction solution, or approx. 25 uses at 2mg reagent per use
50mg Product Instructions for product #22416 SMPB MSDS for product #22416 SMPB Certificate of Analysis for product #22416 SMPB $154.00

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Instructions | MSDS | CofA
Product Instructions | MSDS | CofA  

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