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A short, NHS-ester and iodoacetyl crosslinker for amine-to-sulfhydryl conjugation.

Pierce SIAB

Thermo Scientific Pierce SIAB is a mid-length (10.6 angstrom) crosslinker for amine-to-sulfhydryl conjugation via N-hydroxysuccinimide (NHS) ester and iodoacetyl reactive groups.


  • Reactive groups: NHS ester and iodoacetyl
  • Reactive toward: amino and sulfhydryl groups
  • Non-cleavable
  • Water-insoluble (dissolve first in DMF or DMSO); compare to Sulfo-SIAB
  • Used to prepare stable enzyme-IgG conjugates
  • Forms conjugates with liposomes

Product Details:

Succinimidyl (4-iodoacetyl)aminobenzoate; SIAB
Chemical structure of SIAB crosslinking reagent.

Product References:

Crosslinker Application Guide -- search for recent literature references for this product

Related Resources:

Overview of crosslinking
Chemistry of crosslinking

Related Products:

Crosslinkers at a glance (selection guide)

Ordering Information
Product # Description Pkg. Size Instructions MSDS CofA Price
22329 SIAB
Formulation: Succinimidyl (4-iodoacetyl)aminobenzoate; powder solid
Sufficient For: 124mL of typical 1X (1mM) reaction solution, or approx. 25 uses at 2mg reagent per use
50mg Product Instructions for product #22329 SIAB MSDS for product #22329 SIAB Certificate of Analysis for product #22329 SIAB $256.00

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Instructions | MSDS | CofA
Product Instructions | MSDS | CofA  

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