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Octyl-beta-Thioglucoside (OTG)

Stabilizes proteins better than octyl beta-glucoside.

Octylthioglucoside (OTG)

Thermo Scientific Octylthioglucoside is a low-MW nonionic detergent that is effective for cell lysis and nondenaturing protein solubilization. It is resistant to beta-D-glucoside glucohydrolase degradation.


  • A low-molecular weight, nonionic detergent
  • Effective for a variety of cell lysis and protein solubilization methods
  • Unaffected by beta-glucosidase enzyme
  • More stable than octyl beta-glucoside (OG)
  • Can be removed from solution by dialysis
  • Optically clear; low absorbance at 280nm

Product Details:

Chemical structure of n-Octyl-beta-D-thioglucopyranoside detergent
Chemical structure of n-Octyl-β-D-thioglucopyranoside detergent.

Properties of n-Octyl-β-D-thioglucopyranoside:

  • Alternative Names: Octylthioglucoside, OTG
  • Chemical Name: n-Octyl-β-D-thioglucopyranoside
  • Molecular Weight: 308.44g
  • Detergent Class: Nonionic
  • Aggregation Number: Unknown
  • Micelle Molecular Weight: Unknown
  • Critical Micelle Concentration (CMC): 9mM (0.2772%, w/v)
  • Cloud Point: >100°C
  • Dialyzable: Yes

Specifications for Octylthioglucoside (OTG) (Part No. 28351):

  • Visual: White powder, free of foreign material.
  • Solubility: Solution must be clear, colorless and free of particulate matter.
  • Identity: The IR scan must show only peaks characteristic for the structure and functional groups of the compound being tested.


  1. Saito, S., et al. (1984). J. Biochem. 222, 829-832.
  2. Hanatani, M., et al. (1989). J. Biochem. 95, 1349-1353.

Related Resources:

Review of detergents for cell lysis

Related Products:

Detergent Sampler Pack
Other Detergents for Protein Methods
Detergent Removal Resins

Ordering Information
Product # Description Pkg. Size Instructions MSDS CofA Price
28351 Octylthioglucoside (OTG)
Formulation: n-Octyl beta-D-thioglucopyranoside
5g MSDS for product #28351 Octylthioglucoside (OTG) Certificate of Analysis for product #28351 Octylthioglucoside (OTG) $214.00

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Instructions | MSDS | CofA
Product Instructions | MSDS | CofA  

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