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A nonionic detergent widely used for membrane protein solubilization.


Thermo Scientific Octyl-beta-Glucoside is a nonionic detergent that has been widely used for membrane protein solubilization.


  • A low-molecular weight, nonionic detergent
  • Effective for membrane protein solubilization
  • Less stable and less commonly used than octylthioglucoside (OTG)
  • Can be removed from solution by dialysis
  • Optically clear; low absorbance at 280nm


Product Details:

Chemical structure of Octyl-beta-glucoside detergent
Chemical structure of N-Octyl-β-D-glucoside detergent.

Properties of N-Octyl-β-D-glucoside:

  • Alternative Names: Octyl-beta-glucoside, OG, Octyl-beta-glucopyranoside, Octyl-beta-D-glucopyranoside
  • Chemical Name: n-Octyl-β-D-glucoside
  • Molecular Weight: 292.37g
  • Detergent Class: Nonionic
  • Aggregation Number: 27
  • Micelle Molecular Weight: 8000g
  • Critical Micelle Concentration (CMC): 23 to 25mM (0.6716 to 0.7300%, w/v)
  • Cloud Point: >100°C
  • Dialyzable: Yes

Specifications for Octyl-beta-Glucoside (Part No. 28309, 28310):

  • Visual: White, free-flowing powder, free of foreign material.
  • Solubility: A 20% (D.I. water) solution must be clear, colorless, with no particulates.
  • Absorbance (400nm) of a 20% solution: <0.025
  • Absorbance (280nm) of a 20% solution: <0.300
  • Specific Rotation (20°C, 1%): -29.0 to -32.0°C
  • Identity: The IR scan must show only peaks characteristic for the structure and functional groups of the compound being tested.


  1. Rosevear, P., et al. (1980). Biochemistry 19, 4108-4115.
  2. Gould, R.J., et al. (1981). Biochemistry 20, 6776-6781.
  3. Jackson, M.L., et al. (1982). Biochemistry 21, 4576-4582.

Related Resources:

Review of detergents for cell lysis

Related Products:

Detergent Sampler Pack
Other Detergents for Protein Methods
Detergent Removal Resins

Ordering Information
Product # Description Pkg. Size Instructions MSDS CofA Price
28310 Octyl-beta-Glucoside
Formulation: n-Octyl-beta-D-glucoside
5g MSDS for product #28310 Octyl-beta-Glucoside Certificate of Analysis for product #28310 Octyl-beta-Glucoside $323.00

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Instructions | MSDS | CofA
Product Instructions | MSDS | CofA  

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