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Premium Grade EDC


Thoroughly tested, highly characterized and fully documented batches of reagent.

Pierce Premium Grade EDC Crosslinker

Thermo Scientific Pierce Premium Grade EDC is our highest quality formulation of this popular carbodiimide crosslinker, specially characterized for applications where product integrity and risk minimization are paramount.

Compared to the standard grade product, Premium Grade EDC provides more clearly defined quality and product support by including (a) increased analytical testing and product characterization, (b) greater batch-specific information and quality assurance review, (c) extensive lot sample retention and (d) change control notification. EDC is 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride, a water-soluble carbodiimide crosslinker that activates carboxyl groups for spontaneous reaction with primary amines, enabling peptide immobilization and hapten-carrier protein conjugation. In the presence of N-hydroxysulfosuccinimide (sulfo-NHS), EDC can be used to convert carboxyl groups to amine-reactive sulfo-NHS esters. This is accomplished by mixing the EDC with a carboxyl containing molecule and adding sulfo-NHS.

Highlights:

  • EDC – carbodiimide crosslinker for conjugation between carboxylates and amines
  • High quality – identity and purity confirmed by several tests
  • Product integrity – enhanced level of testing and characterization compared to standard grade
  • Lot retention – ample supply of past lots retained to ensure future process testing
  • Change management – Change Control Notification (CCN) service
  • Consistent manufacture – batch-specific manufacturing documentation review

Applications:

Product Details:

1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; EDC
 
Chemical structure of EDC crosslinking reagent. For more complete information about the chemical properties and uses of this reagent, see the product page for standard grade EDC.

 

Specifications of Premium Grade EDC. We manufacture crosslinking reagents to ensure the highest possible overall product integrity, consistency and performance for the intended research applications.
Test Premium Grade Specification Standard Grade
Visual White crystalline powder, free of foreign matter Yes
Identity IR scan shows only peaks characteristic of EDC Yes
Water content Karl Fischer titration, ≤ 2%
Trace metals All metals, including lead, ≤ 50 ppm
Elemental analysis Reported values for C, H, and N

Product References:

Crosslinker Application Guide -- search for recent literature references for this product

Related Resources:

Overview of crosslinking
Chemistry of crosslinking

Related Products:

Premium Grade Reagents – complete menu
EDC (standard grade)
Sulfo-NHS (Premium Grade)
Sulfo-NHS (standard grade)
Crosslinkers at a glance (selection guide)


Ordering Information
 
Product # Description Pkg. Size Instructions MSDS CofA Price
PG82079 Premium Grade EDC
Formulation: 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; crystalline powder
Sufficient For: 2.61L of typical 1X (2mM) reaction solution
1g Product Instructions for product #PG82079 Premium Grade EDC MSDS for product #PG82079 Premium Grade EDC Certificate of Analysis for product #PG82079 Premium Grade EDC $75.00

Add to cart
PG82073 Premium Grade EDC
Formulation: 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; crystalline powder
Sufficient For: 62.5L of typical 1X (2mM) reaction solution
25g Product Instructions for product #PG82073 Premium Grade EDC MSDS for product #PG82073 Premium Grade EDC Certificate of Analysis for product #PG82073 Premium Grade EDC $350.00

Add to cart
PG82074 Premium Grade EDC
Formulation: 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; crystalline powder
Sufficient For: 1240L of typical 1X (2mM) reaction solution
500g Product Instructions for product #PG82074 Premium Grade EDC MSDS for product #PG82074 Premium Grade EDC Certificate of Analysis for product #PG82074 Premium Grade EDC $2,700.00

Add to cart

Instructions | MSDS | CofA
Product Instructions | MSDS | CofA  

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