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DST (Disuccinimidyl tartarate)

A periodate-cleavable, amine-to-amine crosslinker.

Pierce DST

Thermo Scientific Pierce DST, also called disuccinimidyl tartrate, is a water-soluble crosslinker that contains amine-reactive NHS ester ends around a 4-atom spacer arm, whose central diol can be cleaved by periodate oxidation.


  • Reactive groups: NHS ester (both ends)
  • Reactive towards: amino groups (primary amines)
  • Soluble in DMSO or DMF at a concentration of ~10mM (3mg/mL)
  • Cleavable by sodium meta-periodate (Part No. 20504)
  • Ideal for applications in which crosslink cleavability is desired without disturbing protein disulfide bonds

Product Details:

Disuccinimidyl tartrate; DST
Chemical structure of DST crosslinking reagent.


  1. Farries, T.C. and Atkinson, J.P. (1989). Biosynthesis of properdin. J. Immunol. 142, 842-847.
  2. Park, L.S., Friend, D., Gillis, S. and Urdal, D.L. (1986). Characterization of the cell surface receptor for a multi-lineage colony-stimulating factor (CSF-2 ). J. Biol. Chem. 261, 205-210.

Product References:

Crosslinker Application Guide -- search for recent literature references for this product

Related Resources:

Overview of crosslinking
Chemistry of crosslinking

Related Products:

Crosslinkers at a glance (selection guide)

Ordering Information
Product # Description Pkg. Size Instructions MSDS CofA Price
20589 DST
Formulation: Disuccinimidyl tartrate; powder solid
Sufficient For: 145mL of typical 1X (1mM) reaction solution, or approx. 25 uses at 2mg reagent per use
50mg Product Instructions for product #20589 DST MSDS for product #20589 DST Certificate of Analysis for product #20589 DST $197.00

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Instructions | MSDS | CofA
Product Instructions | MSDS | CofA  

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