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DSG (Disuccinimidyl glutarate)

A slightly shorter analog of the popular DSS crosslinker.

Pierce DSG

Thermo Scientific Pierce DSG is disuccinimidyl glutarate, a simple homobifunctional crosslinker based on the amine-reactive N-hydroxysuccinimide (NHS) ester group.


  • Reactive groups: NHS ester (both ends)
  • Reactive towards: amino groups (primary amines)
  • Non-cleavable
  • Water-insoluble (dissolve first in DMF or DMSO)
  • Membrane-permeable, allowing for intracellular crosslinking
  • Can increase crosslinking efficiency compared to DSS in some applications


Product Details:

Disuccinimidyl glutarate; DSG
Chemical structure of DSG crosslinking reagent.


  1. Dihazi, G.H. and Sinz, A. (2003). Rapid Commun. Mass Spectrom. 17, 2005-2014.
  2. Muller, D.R., et al. (2001). Anal. Chem. 73, 1927-1934.
  3. Sinz, A. (2003). J. Mass Spectrom. 38, 1225-1237.
  4. Waugh, S.M., DiBella, E.E. and Pilch, P.F. (1989). Biochemistry 28, 3448-3455.

Product References:

Crosslinker Application Guide -- search for recent literature references for this product

Related Resources:

Overview of crosslinking
Chemistry of crosslinking

Related Products:

Crosslinkers at a glance (selection guide)

Ordering Information
Product # Description Pkg. Size Instructions MSDS CofA Price
20593 DSG
Formulation: Disuccinimidyl glutarate; powder solid
Sufficient For: 153mL of typical 1X (1mM) reaction solution, or approx. 25 uses at 2mg reagent per use
50mg Product Instructions for product #20593 DSG MSDS for product #20593 DSG Certificate of Analysis for product #20593 DSG $84.00

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Instructions | MSDS | CofA
Product Instructions | MSDS | CofA  

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