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DMS (Dimethyl Suberimidateā€¢2 HCl)

Creates 11-angstrom crosslinks between amines while maintaining overall charge properties.

Pierce DMS

Thermo Scientific Pierce DMS is dimethyl suberimidate, a membrane-permeable crosslinker that contains an amine-reactive imidoester group at each end of an 8-atom spacer arm.


  • Reactive groups: imidoester (both ends)
  • Reactive towards: amino groups (primary amines)
  • Longest of three similar imidoester crosslinkers, which include DMA, DMP and DMS
  • Water-soluble
  • Imidoesters react with amines at alkaline pH values (pH 8-10) to form amidine bond
  • Amidine bond retains net charge character of protein primary amine to which it reacts
  • Reversible at high pH values
  • Tool for study of quarternary structure of proteins

Product Details:

Dimethyl suberimidate-2HCl; DMS
Chemical structure of DMS crosslinking reagent.


  1. Dihazi, G.H. and Sinz, A. (2003). Rapid Commun. Mass Spectrom. 17, 2005-2014.
  2. Wang, D. and Moore, S. (1977). 16(13), 2937-2941.

Product References:

Crosslinker Application Guide -- search for recent literature references for this product

Related Resources:

Overview of crosslinking
Chemistry of crosslinking
Fixation strategies and formulations for immunohistochemistry

Related Products:

Crosslinkers at a glance (selection guide)

Ordering Information
Product # Description Pkg. Size Instructions MSDS CofA Price
20700 DMS
Formulation: Dimethyl suberimidate-2HCl; powder-granule solid
Sufficient For: 3660mL of typical 1X (1mM) reaction solution, or approx. 500 uses at 2mg reagent per use
1g Product Instructions for product #20700 DMS MSDS for product #20700 DMS Certificate of Analysis for product #20700 DMS $123.00

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Instructions | MSDS | CofA
Product Instructions | MSDS | CofA  

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