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DMP (Dimethyl pimelimidateā€¢2 HCl)


Creates 9-angstrom crosslinks between amines while maintaining overall charge properties.

Pierce DMP

Thermo Scientific Pierce DMP is dimethyl pimelimidate, a membrane-permeable crosslinker that contains an amine-reactive imidoester group at each end of a 7-atom spacer arm.

Highlights:

  • Reactive groups: imidoester (both ends)
  • Reactive towards: amino groups (primary amines)
  • Mid-length reagent of three similar imidoester crosslinkers, which include DMA, DMP and DMS
  • Water-soluble
  • Imidoesters react with amines at alkaline pH values (pH 8-10) to form amidine bond
  • Amidine bond retains net charge character of protein primary amine to which it reacts
  • Reversible at high pH values
  • Tool for study of quarternary structure of proteins

Product Details:

Dimethyl pimelimidate-2HCl; DMP
 
Chemical structure of DMP crosslinking reagent.

References:

  1. Bauer P.I., et al. (1990). Biochem. J. 270(1), 17-26.
  2. O’Keeffe, E.T., et al. (1980). Biochemistry 19(22), 4962-4966.
  3. Schneider, C., et al. (1982). J. Biol. Chem. 257(18), 10766-10769.
  4. Sinha, S.K. and Brew, K. (1981). J. Biol. Chem. 256(9), 4193-4204.

Product References:

Crosslinker Application Guide -- search for recent literature references for this product

Related Resources:

Overview of crosslinking
Chemistry of crosslinking

Related Products:

Crosslinkers at a glance (selection guide)


Ordering Information
 
Product # Description Pkg. Size Instructions MSDS CofA Price
21666 DMP
Formulation: Dimethyl pimelimidate-2HCl; powder solid
Sufficient For: 193mL of typical 1X (1mM) reaction solution, or approx. 25 uses at 2mg reagent per use
50mg Product Instructions for product #21666 DMP MSDS for product #21666 DMP Certificate of Analysis for product #21666 DMP $41.00

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21667 DMP
Formulation: Dimethyl pimelimidate-2HCl; powder solid
Sufficient For: 3858mL of typical 1X (1mM) reaction solution, or approx. 500 uses at 2mg reagent per use
1g Product Instructions for product #21667 DMP MSDS for product #21667 DMP Certificate of Analysis for product #21667 DMP $53.00

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Instructions | MSDS | CofA
Product Instructions | MSDS | CofA  

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