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An organic-soluble carbodiimide crosslinker frequently used for peptide synthesis.

Pierce DCC

Thermo Scientific Pierce DCC is dicyclohexylcarbodiimide, an organic-soluble crosslinker that activates carboxyl groups for spontaneous peptide-bond formation with primary amines.


  • Reactive group: carbodiimide
  • Reaction target: activates carboxyl groups to conjugate to amino groups (primary amines)
  • Zero-length crosslinker
  • Water-insoluble (dissolve in organic solvent)


  • Non-aqueous organic synthesis methods
  • Use with NHS to create custom NHS ester-activated, amine-modifying reagents
  • Immobilize small molecules onto carboxylate-containing supports

Product Details:

Dicyclohexylcarbodiimide; DCC
Chemical structure of DCC crosslinking reagent.

Product References:

Crosslinker Application Guide -- search for recent literature references for this product

Related Resources:

Overview of crosslinking
Chemistry of crosslinking

Related Products:

Crosslinkers at a glance (selection guide)

Ordering Information
Product # Description Pkg. Size Instructions MSDS CofA Price
20320 DCC
Formulation: Dicyclohexylcarbodiimide
Sufficient For: 240L of typical 1X (2mM) reaction solution, or thousands of uses at 2mg reagent per use
100g MSDS for product #20320 DCC Certificate of Analysis for product #20320 DCC $111.00

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Instructions | MSDS | CofA
Product Instructions | MSDS | CofA  

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