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BSOCOES (Bis[2-(succinimidooxycarbonyloxy)ethyl]sulfone)

A base-cleavable reagent for reversible crosslinking between amines.


Thermo Scientific Pierce BSOCOES is a homobifunctional NHS-ester crosslinker with a base-cleavable spacer arm for reversible crosslinking between primary amines.


  • Reactive groups: NHS ester (both ends)
  • Reactive towards: amino groups (primary amines)
  • Base-cleavable (pH 11.6, 2 hours, 37°C)
  • Water-insoluble (dissolve first in DMF or DMSO)
  • Membrane-permeable, allowing for intracellular crosslinking


Product Details:

Bis[2-(succinimidooxycarbonyloxy)ethyl]sulfone; BSOCOES
Chemical structure of BSOCOES crosslinking reagent.


  1. Bouizar, Z., Fouchereau-Person, M., Taboulet, J., Moukhtar, M.S. and Milhaud, G. (1986). Purification and characterization of calcitonin receptors in rat kidney membranes by covalent crosslinking techniques. Eur. J. Biochem. 155, 141-147.
  2. Zarling, D.A., Watson, A. and Bach, F.H. (1980). Mapping of lymphocyte surface polypeptide antigens by chemical crosslinking with BSOCOES. J. Immunol. 124, 913-920.

Product References:

Crosslinker Application Guide -- search for recent literature references for this product

Related Resources:

Overview of crosslinking
Chemistry of crosslinking

Related Products:

Crosslinkers at a glance (selection guide)

Ordering Information
Product # Description Pkg. Size Instructions MSDS CofA Price
Formulation: Bis[2-(succinimidooxycarbonyloxy)ethyl]sulfone; powder solid
Sufficient For: 115mL of typical 1X (1mM) reaction solution, or approx. 25 uses at 2mg reagent per use
50mg Product Instructions for product #21600 BSOCOES MSDS for product #21600 BSOCOES Certificate of Analysis for product #21600 BSOCOES $139.00

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Instructions | MSDS | CofA
Product Instructions | MSDS | CofA  

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