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An amine-to-sulfhydryl crosslinker with a short spacer arm (5.9 angstroms).

Pierce BMPS

Thermo Scientific Pierce BMPS is an amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a short spacer arm (5.9 angstroms).


  • Reactive groups: NHS ester and maleimide
  • Reactive towards: amino and sulfhydryl groups
  • C3-homolog of aliphatic spacer series which includes AMAS, BMPS, GMBS and EMCS
  • NHS ester end couples with primary amines at pH 7-9, forming stable amide bonds
  • Maleimide reacts with -SH groups at pH 6.5-7.5, forming stable thioether linkages
  • Non-cleavable
  • Water-insoluble (dissolve first in DMF or DMSO)
  • Short aliphatic spacer has low potential for eliciting an immune response

Product Details:

N-beta-Maleimidopropyl-oxysuccinimide ester; BMPS
Chemical structure of BMPS crosslinking reagent.


  1. McKenzie, J.A., Raison, R.L. and Rivett, E.E. (1988). Development of a bifunctional crosslinking agent with potential for the preparation of immunotoxins. J. Protein Chem. 7(5), 581-592.
  2. Kitagawa, T., et al. (1981). Chem. Pharm. Bull. 29(4), 1130-1135.
  3. Kitagawa, T. (1981). "Enzyme labeling with N-hydroxysuccinimidyl ester of maleimide", In Ishikawa, E., Kawai, T. and Miyai, K. (Eds.), Enzyme Immuno-assay (pp. 81-89). IGAKU-SHOIN, Tokyo-New York.

Product References:

Crosslinker Application Guide -- search for recent literature references for this product

Related Resources:

Overview of crosslinking
Chemistry of crosslinking

Related Products:

Crosslinkers at a glance (selection guide)

Ordering Information
Product # Description Pkg. Size Instructions MSDS CofA Price
22298 BMPS
Formulation: N-beta-Maleimidopropyl-oxysuccinimide ester; solid
Sufficient For: 188mL of typical 1X (1mM) reaction solution, or approx. 25 uses at 2mg reagent per use
50mg Product Instructions for product #22298 BMPS MSDS for product #22298 BMPS Certificate of Analysis for product #22298 BMPS $111.00

Now available on lifetechnologies.com
22298B BMPS
Formulation: N-beta-Maleimidopropyl-oxysuccinimide ester; solid
Custom MSDS for product #22298B BMPS Certificate of Analysis for product #22298B BMPS Bulk Quote Request

Instructions | MSDS | CofA
Product Instructions | MSDS | CofA  

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