Long, pegylated, sulfhydryl-to-sulfhydryl crosslinkers, composed of maleimide groups and 2- or 3-unit polyethylene glycol spacer arm
PEG spacers provide unique advantages, including enhanced solubility, increased stability, reduced tendency toward aggregation and reduced immunogenicity
Pure compounds with defined structure and molecular weight, ensuring reproducible protein-modification effects
Ideal for small molecule or peptide conjugations
Chemical structures of BM(PEG)2 and BM(PEG)3 crosslinking reagents. Thermo Scientific Pierce BM(PEG)2 is a pegylated crosslinker having the form maleimide-PEG-maleimide for conjugation between sulfhydryl groups (e.g., cysteines) via a two-unit polyethylene glycol (PEG) spacer arm (14.7 angstroms). Thermo Scientific Pierce BM(PEG)3 has a three-unit polyethylene glycol (PEG) spacer arm (17.8 angstroms).