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A long-arm, maleimide crosslinker for sulfhydryl conjugation.

Pierce BMH

Thermo Scientific Pierce BMH is a long-arm, maleimide crosslinker for covalent, irreversible conjugation between sulfhydryl groups (e.g., protein or peptide cysteines).


  • Reactive groups: maleimide (both ends)
  • Reactive towards: sulfhydryl groups
  • Long (13.0A), sulfhydryl-to-sulfhydryl crosslinker, composed of maleimide groups and 11-atom spacer arm
  • Water-insoluble – dissolve first in DMF or DMSO, then add to aqueous reaction buffers
  • Noncleavable

Product Details:

Bismaleimidohexane; BMH
Chemical structure of BMH crosslinking reagent.


  1. Chen, L.L., et al. (1991). Production of multimeric forms of CD4 through a sugar-based crosslinking strategy. J. Biol. Chem. 266(27), 18237-18243.
  2. Hansen, M.S.T. and Barklis, E. (1995). J. Virol. 69(2), 1150-1159.
  3. Ikushiro, S., et al. (1997). Biochemistry 36(23), 7154-7161.
  4. Schmidt, C.J., et al. (1992). J. Biol. Chem. 267(20), 13807-13810.

Product References:

Crosslinker Application Guide -- search for recent literature references for this product

Related Resources:

Overview of crosslinking
Chemistry of crosslinking

Related Products:

Crosslinkers at a glance (selection guide)

Ordering Information
Product # Description Pkg. Size Instructions MSDS CofA Price
22330 BMH
Formulation: Bismaleimidohexane; powder solid
Sufficient For: 905mL of typical 1X (0.2mM) reaction solution, or approx. 25 uses at 2mg reagent per use
50mg Product Instructions for product #22330 BMH MSDS for product #22330 BMH Certificate of Analysis for product #22330 BMH $109.00

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Instructions | MSDS | CofA
Product Instructions | MSDS | CofA  

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