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BMDB


A mid-length, periodate-cleavable, maleimide crosslinker for sulfhydryl conjugation.

Pierce BMDB

Thermo Scientific Pierce BMDB is a mid-length, periodate-cleavable, maleimide crosslinker for covalent but reversible conjugation between sulfhydryl groups (e.g., protein or peptide cysteines).

 

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Highlights:

  • Reactive groups: maleimide (both ends)
  • Reactive towards: sulfhydryl groups
  • Mid-length (10.2A), periodate-cleavable, sulfhydryl-to-sulfhydryl crosslinker, composed of maleimide groups and 9-atom, diol-containing spacer arm
  • Water-insoluble – dissolve first in DMF or DMSO, then add to aqueous reaction buffers
  • Cleavable by oxidation of spacer arm diol with 15mM sodium periodate (Part No. 20504)

Product Details:

1,4 Bismaleimidyl-2,3-dihydroxybutane; BMDB
 

References:

  1. Stalteri, M.A. and Mather, S.J. (1995). Bioconj. Chem. 6, 179-186.
  2. Yi, F., et al. (1991). J. Biol. Chem. 266(6), 3900-3906.
  3. O’Sullivan, M.J., et al. (1979). Anal. Biochem. 100, 100-108.

Product References:

Crosslinker Application Guide -- search for recent literature references for this product

Related Resources:

Overview of crosslinking
Chemistry of crosslinking

 

Notice:

This reagent is temporarily unavailable.

We apologize for the inconvenience.

 

Related Products:

Crosslinkers at a glance (selection guide)

 

 

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Instructions | MSDS | CofA
Product Instructions | MSDS | CofA  

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