Thermo Fisher Scientific Introduces New Tools for Studying GTPases and Large G-protein Subunits

By Kevin


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Name: Monica O’Hara
Phone: +1 815-968-0747


ROCKFORD, Ill. (Feb. 9, 2011) – Thermo Fisher Scientific, the world leader in serving science, today introduced the Thermo Scientific Pierce GTPase Enrichment Kit for profiling small GTPases and large G-protein subunits. The kit provides the reagents for the broad enrichment of GTPbinding proteins from tissues, cells and subcellular proteomes.

The Pierce* GTPase Enrichment Kit expands on the use of novel desthiobiotin-nucleotide probes that are also found in the new Thermo Scientific Pierce Kinase Enrichment Kits. The nucleotide is attached to desthiobiotin, a biotin analog developed by ActivX Biosciences. The nucleotide binds to the active site of the GTP-binding protein, and the desthiobiotin tag allows for capture and enrichment of the bound protein. The desthiobiotin tag binds less tightly to biotinbinding proteins, making the capture bond easily reversible by biotin displacement, low pH or heat. The isolated proteins then can be further studied by Western blot analysis or mass spectrometry.

This kit provides all labeling and enrichment reagents, including the ActivX GTP probe. The ActivX Probe is also available separately. For more details on the Pierce GTPase Enrichment Kit, please visit

About Thermo Fisher Scientific

Thermo Fisher Scientific Inc. (NYSE: TMO) is the world leader in serving science. Our mission is to enable our customers to make the world healthier, cleaner and safer. With revenues of nearly $11 billion, we have approximately 37,000 employees and serve customers within pharmaceutical and biotech companies, hospitals and clinical diagnostic labs, universities, research institutions and government agencies, as well as in environmental and process control industries. We create value for our key stakeholders through two premier brands, Thermo Scientific and Fisher Scientific, which offer a unique combination of continuous technology development and the most convenient purchasing options. Our products and services help accelerate the pace of scientific discovery, and solve analytical challenges ranging from complex research to routine testing to field applications. Visit

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GTPase Enrichment Kit and Probes

GTPase Enrichment Kit and Probes

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