ActivX Fluorophosphonate (FP) Probes allow covalent labeling of the serine hydrolase active site with affinity, fluorescent or reactive tags to facilitate selective enrichment, detection or multiplex labeling.

Thermo Fisher Scientific Announces New Chemiluminescent Option for Western Blot Detection

By Kevin


Media Contact Information:
Name: Monica O’Hara
Phone: +1 815-968-0747


ROCKFORD, Ill. (April 15, 2011) – Thermo Fisher Scientific, the world leader in serving science, today announced the introduction of novel reagents for the study of active serine hydrolases. The Thermo Scientific ActivX Serine Hydrolase Probes contain a fluorphosphonate (FP) element that specifically binds to the active site of serine hydrolases. The probes enable enrichment of serine hydrolase enzymes and determination of enzymatic activity using fluorescent SDS-PAGE, Western blot or mass spectrometry (MS) workflows.

Three ActivX* Serine Hydrolase Probes are available. The ActivX TAMRA-FP Probes can be used to label and detect serine hydrolase activity in samples using fluorescent gel imaging, capillary electrophoresis or MS. The ActivX Azido-FP Probes can be used in combination with phosphine- or alkyne-derivatized tags for detection or enrichment. Lastly, the ActivX Desthiobiotin-FP Probes can be used for detection and enrichment of active-site-labeled proteins by Western blot and MS.

The ActivX Serine Hydrolase Probes provide sufficient reagent for 100 labeling reactions or 10 pull-down reactions. The probes store easily at -80°C for up to one year. For more information on the probes, please visit

About Thermo Fisher Scientific

Thermo Fisher Scientific Inc. (NYSE: TMO) is the world leader in serving science. Our mission is to enable our customers to make the world healthier, cleaner and safer. With revenues of nearly $11 billion, we have approximately 37,000 employees and serve customers within pharmaceutical and biotech companies, hospitals and clinical diagnostic labs, universities, research institutions and government agencies, as well as in environmental and process control industries. We create value for our key stakeholders through two premier brands, Thermo Scientific and Fisher Scientific, which offer a unique combination of continuous technology development and the most convenient purchasing options. Our products and services help accelerate the pace of scientific discovery, and solve analytical challenges ranging from complex research to routine testing to field applications. Visit

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ActivX Fluorophosphonate Probes

ActivX Fluorophosphonate Probes

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