Calibration solutions for mass spectrometry

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Featured Products:

Pierce LTQ ESI Positive Ion Calibration Solution

Pierce LTQ ESI Positive Ion Calibration Solution

Pierce LTQ Velos ESI Positive Ion Calibration Solution

Pierce LTQ Velos ESI Positive Ion Calibration Solution

Pierce Negative Ion Calibration Solution

Pierce Negative Ion Calibration Solution

Pierce Triple Quadrupole Calibration Solution

Pierce Triple Quadrupole Calibration Solution


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Author Affiliations:

Thermo Fisher Scientific, Rockford, IL
Except: (1) Thermo Fisher Scientific, San Jose, CA.

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Monica Noonan

Managing Editor:

Douglas Hayworth


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Calibration solutions for Thermo Scientific Mass Spectrometers

Ready-to-use standards enable quick instrument calibration.

John C. Rogers, Ph.D.; Michael M. Rosenblatt, Ph.D.; Eugene J. Cichon, B.S.; Rosa Viner, Ph.D.1; Monica Noonan, M.S.;

June 1, 2011


Routine calibration of mass spectrometers is required for optimal performance. Our new calibration solutions for Thermo Scientific Mass Spectrometers are ready-to-use liquid formulations for quick and easy instrument calibration.

Calibration solutions for Thermo Scientific Ion Trap and Orbitrap Mass Spectrometers

Calibration of Thermo Scientific Ion Trap and Orbitrap Mass Spectrometers is required for proper instrument performance. These high-quality calibration solutions are for regulated environments and busy laboratories and avoid time-consuming reagent preparation. Reagents are provided in high-purity Teflon*-coated containers tested rigorously to provide the highest batch-to-batch reproducibility (Figures 1 and 2).

Velos ESI Positive Ion Calibration Solution spectrum

Figure 1. Representative mass spectrum for the Thermo Scientific Pierce LTQ Velos ESI Positive Ion Calibration Solution.N-butylamine, caffeine, Met-Arg-Phe-Ala (MRFA) and Ultramark 1621 are used to calibrate Thermo Scientific LTQ Velos Ion Trap and Orbitrap Mass Spectrometers in the ESI positive ionization mode. The N-butylamine is included to extend to low mass calibration range.

ESI Negative Ion Calibration Solution spectrum

Figure 2. Representative mass spectrum for the negative ion calibration. Sodium dodecyl sulfate, sodium taurocholate and Ultramark 1621, comprise the calibration mixture used to calibrate Ion Trap and Orbitrap* Mass Spectrometers in the negative ionization mode.

Calibration solutions for Thermo Scientific Triple Quadrupole Mass Spectrometers

Thermo Scientific TSQ Mass Spectrometers are calibrated with multimers of tyrosine (Tyr1, Tyr3, Tyr6). All of the components of this mixture are prepared from the highest purity raw materials and are stored in inert Teflon-coated containers (Figure 3).

Triple Quadrapole Calibration Solution spectrum

Figure 3. Representative mass spectrum for the triple-quadrupole MS calibration. Multimers of tyrosine are used to calibrate the TSQ series of Triple Quadrupole Mass Spectrometers.