Update profile
    Change password
    Sign out

Amino Acid Physical Properties

Amino acids are the building blocks of peptides and proteins, and while they all have common elements of an amine group, a carboxyl group and a side chain, the various functional groups that comprise the side chain give each amino acid distinct physical properties that influence protein formation and function. Understanding these physical properties, including charge, solubility and pKa, aid in designing peptide sequences that are optimized for high synthesis yield and purity. To simplify the handling of peptide sequences, each amino acid has a designated single-letter code.

The table below includes the single-letter codes and physical properties of the 20 standard amino acids.

Protein Methods Library Home

Amino acid physical properties.
Amino Acid Code Hydropathy Charge pKa, NH2 pKa, COOH pK(R) Solubility
Arginine R hydrophilic + 9.09 2.18 13.2 71.8
Asparagine N hydrophilic N 8.8 2.02   2.4
Aspartate D hydrophilic - 9.6 1.88 3.65 0.42
Glutamate E hydrophilic - 9.67 2.19 4.25 0.72
Glutamine Q hydrophilic N 9.13 2.17   2.6
Lysine K hydrophilic + 10.28 8.9 2.2  
Serine S hydrophilic N 9.15 2.21   36.2
Threonine T hydrophilic N 9.12 2.15   freely
Cysteine C moderate N 10.78 1.71 8.33 freely
Histidine H moderate + 8.97 1.78 6 4.19
Methionine M moderate N 9.21 2.28   5.14
Alanine A hydrophobic N 9.87 2.35   15.8
Valine V hydrophobic N 9.72 2.29   5.6
Glycine G hydrophobic N 9.6 2.34   22.5
Isoleucine I hydrophobic N 9.76 2.32   3.36
Leucine L hydrophobic N 9.6 2.36   2.37
Phenylalanine F hydrophobic N 9.24 2.58   2.7
Proline P hydrophobic N 10.6 1.99   1.54
Tryptophan W hydrophobic N 9.39 2.38   1.06
Tyrosine Y hydrophobic N 9.11 2.2 10.1 0.038

 

Learn more...

Custom Peptide Modifications

View products...

Custom Peptide Synthesis Service

HeavyPeptide Custom Synthesis Service

PEPotec Custom Peptide Libraries


Instructions | MSDS | CofA
Product Instructions | MSDS | CofA  

Recommend this page

Follow Us
Email Sign-up  Email Announcements

 



Antibodies  |   Molecular Biology   |   Cell Biology   |  Thermo Scientific  |   * Trademarks  |   Privacy Statement
© 2014 Thermo Fisher Scientific Inc.   |   3747 N Meridian Rd, Rockford, IL USA 61101   |   1-800-874-3723  or  815-968-0747