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Pierce Premium Grade Reagents

Highly characterized and thoroughly documented batches of selected reagents.

Pierce Premium Grade Crosslinking, Labeling and Modification ReagentsThermo Scientific Pierce Premium Grade Reagents are high-quality formulations of selected chemical modification reagents, specially characterized for applications where product integrity and risk minimization are paramount. The current menu of reagents offered in this premium format includes several popular crosslinkers, two biotinylation reagents, and a reducing agent. The reagents are ideal for research projects that require long-term, consistent performance and an extra level of troubleshooting support afforded by robust chemical characterization and documentation.

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Protein Methods Library Home

Overview of Crosslinking and Protein Modification

Overview of Biotinylation

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Crosslinkers and Protein Modification Reagents

Biotinylation Reagents


Compared to standard grade equivalents, Premium Grade Reagents provide more clearly defined quality and product support by including each of the following features:

  • increased analytical testing and product characterization
  • greater batch-specific information and quality assurance review
  • more extensive lot sample retention
  • change control notification (CCN)


  • High quality – identity and purity confirmed by several tests, including quantitative NMR
  • Product integrity – enhanced level of testing and characterization compared to standard grade
  • Lot retention – ample supply of past lots retained to ensure future process testing
  • Change management – Change Control Notification (CCN) service
  • Consistent manufacture – batch-specific manufacturing documentation review


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Bulk and Custom Products

Tests and specifications for Premium Grade Reagents compared to standard grade equivalents. We manufacture all reagents to ensure the highest possible overall product integrity, consistency and performance for the intended research applications. The first four tests do not apply to all reagents, but they are used equally for both grades of each to which they are applicable.
Test Parameter Test Method Premium Grade Standard Grade
Purity Quantitative NMR using an internal standard Yes Yes
Visual Color assessment Yes Yes
Solubility Sample dissolves at specified concentration in deionized water to yield a clear, colorless solution Yes Yes
Identity Infrared spectroscopy Yes Yes
Mass identity Mass spectrometry Yes
Water content Karl Fischer titration Yes
Trace metals Inductively coupled plasma mass spectrometry (ICP-MS) Yes
Elemental analysis Combustion analysis (values reported for C, H, N, O and S) Yes
Residual solvent analysis Headspace gas chromatography Upon request


Quick-link Table of Products

Reagent Type  Premium Grade Standard Grade
Carboxyl-to-amine Crosslinkers EDC
Amine-to-amine Crosslinkers BS3
Amine-to-sulfhydryl Crosslinkers Sulfo-SMCC
Biotinylation Reagents Sulfo-NHS-LC-Biotin
Reducing Agents TCEP-HCl TCEP-HCl

Instructions | MSDS | CofA
Product Instructions | MSDS | CofA  

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