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Crosslinker Selection Guide

Find the best available crosslinker for your bioconjugation experiments.

This Crosslinker Selection Guide provides quick access to customized lists of Thermo Scientific Pierce Crosslinkers that meet specific criteria, including target functional group, solubility and cell membrane permeability.

Select the desired features and select the 'Submit' button. Choose "No specific requirement" to see all items. Search results include a list of products in order of crosslinking distance (spacer arm length) with links to individual product pages. Alternatively, view the Crosslinkers at a Glance page or simply browse our entire line of crosslinking reagents.

Water Soluble:
      No specific requirement
Membrane Permeable:
      No specific requirement


  • What is our definition of water soluble? With very few exceptions, all crosslinkers are soluble in miscible organic solvents such as DMSO, DMF or acetonitrile. Typical protocols involve first dissolving the reagent at 10X the working concentration and then adding it to an aqueous reaction mixture. Organic solvents are not compatible with certain applications, and directly aqueous-soluble crosslinkers are preferable in these situations. We classify crosslinkers as water-soluble if they can be dissolved directly in water or aqueous buffers at greater than 1 to 5X the concentration needed for typical procedures.
  • Still need help? Contact Technical Support; our scientists will be glad to help you plan a crosslinking strategy.
Instructions | MSDS | CofA
Product Instructions | MSDS | CofA  

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