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Modification Reagents for Amino Acids

Chemical agents to modify amino acid side chains on proteins and peptides in order to alter native charges, block or expose reactive binding sites, inactivate functions, or change functional groups to create targets for crosslinking and labeling.

Silylation reagent for coating glass and silica surfaces to add primary amines, which can be used to crosslink and immobilize proteins and other molecules. 

Amine-and-carboxyl (amino acid) compound that contains an internal disulfide bond; use with crosslinkers to modify functional groups on proteins and surfaces. 

Amine-reactive compound to reversibly cap lysines and other primary amines with carboxyl groups; stable at pH 7 but hydrolyzes (decouples) at pH 3 to 4. CAS 616-02-4. 

Sulfhydryl-reactive (maleimide) compound to permanently cap protein or peptide cysteines with carboxyl groups (make caproic acid derivatives). 

Aniline (CAS 62-53-3) and optimized buffer to enhance aldehyde-hydrazide crosslinking efficiency for glycoprotein immobilization and conjugation. 

NH2OH (CAS 7803-49-8) to cleave Asn-Gly peptide bonds or deprotect sulfhydryls following S-acetylthioacetate modification with SATA reagent. 

IAA is C2H3IO2 (CAS 64-69-7) to S-carboxymethylate sulfhydryls (reduced cysteines) at slightly alkaline pH for various protein biology methods. 

Methyl methanethiosulfonate (CAS 2949-92-0); reversibly blocks cysteines (sulfhydryl groups) to facilitate study of enzyme activation and protein functions. 

Small, sulfhydryl-reactive (maleimide) compound to permanently block reduced cysteines of proteins or peptides to prevent disulfide bond formation. 

Long (18.2A), pegylated form of SATA, an amine-reactive (NHS ester) sulfhydryl-addition reagent; contains 4-unit polyethylene glycol spacer arm. 

Complete kit with SATA reagent and hydroxylamine to modify protein primary amines to create free sulfhydryl groups for crosslinking techniques. 

Short (4.1A), amine-reactive (NHS ester) sulfhydryl-addition reagent; creates stable (protected yet exposable) -SH group for protein crosslinking strategies. 

NaIO4 (CAS 7790-28-5); to gently oxidize glycoprotein carbohydrate sugars to create reactive aldehydes (carbonyls) for crosslinking and immobilization. 

Amine-reactive (NHS ester) compound to permanently block primary amines (e.g., protein lysine side chains) to prevent interactions or later conjugation. 

Amine-reactive (NHS ester) compound to add a 7-atom spacer arm; the terminal trifluoroacetyl group can be removed later to expose a new primary amine. 

2-Iminothiolane-HCl (CAS 4781-83-3); an amine-reactive thiolation reagent to cap protein primary amines with sulfhydryl groups for immediate crosslinking. 

Instructions | MSDS | CofA
Product Instructions | MSDS | CofA  

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