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Carboxyl-to-Amine Crosslinkers


Carbodiimide crosslinking reagents DCC and EDC (EDAC) for conjugation of carboxyl groups (glutamate, aspartate, C-termini) to primary amines (lysine, N-termini); also N-hydroxysuccinimide (NHS) for stable activation of carboxylates for amine-conjugation.


N, N'-Dicyclohexylcarbodiimide, CAS 538-75-0; carboxyl-to-amine crosslinker and peptide coupling reagent; organic-soluble; used for peptide synthesis. 

1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide, CAS 25952-53-8; carboxyl-to-amine crosslinker; water-soluble for peptide immobilization and protein conjugation. 

EDC carbodiimide crosslinker (carboxyl-to-amine reactive), prepared as thoroughly tested, highly characterized and fully documented batches of reagent. 

Sulfo-NHS crosslinker (for use with EDC), prepared as thoroughly tested, highly characterized and fully documented batches of reagent. 

N-hydroxysuccinimide and N-hydroxysulfosuccinimide; prepare amine-reactive NHS-ester crosslinkers or enhance carbodiimide (EDC) conjugation for peptides or proteins. 

Instructions | MSDS | CofA
Product Instructions | MSDS | CofA  

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