Thermo Scientific Pierce BS(PEG)n Crosslinkers include
BS(PEG)5 and BS(PEG)9, which are bis-succinimide ester-activated PEG
compounds for crosslinking between primary amines in proteins and other
molecules.
BS(PEG)5 and BS(PEG)9 are bis-succinimide ester-activated
PEG compounds for crosslinking between primary amines (–NH2) in proteins
and other molecules. The N-hydroxysuccinimide ester (NHS) groups
at either end of the PEG5 or PEG9 spacer react specifically and
efficiently with lysine and N-terminal amino groups at pH 7-9 to form
stable amide bonds.
Highlights:
- Irreversibly crosslink proteins or peptides by
flexible PEG spacer arms
- Polyethylene glycol spacer arms help maintain
conjugate solubility
- Pure compound with defined structure and
molecular weight, ensuring reproducible protein-modification
effects
- PEG spacer provides unique advantages, including
increased stability, reduced tendency toward aggregation and
reduced immunogenicity
- Ideal for small molecule or peptide
conjugations
- NHS esters react with –NH2 groups at pH 7-9,
forming stable amide bonds
- Reactive groups: NHS esters
(homobifunctional)
- Reactive toward: primary amines
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Alternative Names for BS(PEG)n:
- Bis-NHS-dPEG
- NHS-PEG-NHS
- BS(PEO)5
- Bis(NHS)PEO5
- BS-PEO9
- dPEG NHS ester
- Bis-succinimide ester PEG 400
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Product Details:
Related Products
Non-PEG
Bis-NHS Crosslinkers
Sulfhydryl-reactive PEG
Crosslinkers
Other kinds of PEGylation Reagents
Reference
- Hermanson, G.T. (2008). Bioconjugate Techniques,
Academic Press (Product # 20036)
Crosslinking reagents are available in bulk
quantities with special pricing for manufacturing
applications. |
5-stc.jpg "Bis(succinimidyl) penta(ethylene glycol); BS(PEG)5")
9-stc.jpg "Bis(succinimidyl) nona(ethylene glycol); BS(PEG)9")
