Chemical agents to modify amino acid side chains on proteins and peptides in order to alter native charges, block or expose reactive binding sites, inactivate functions, or change functional groups to create targets for crosslinking and labeling.
Silylation reagent for coating glass and silica surfaces to add primary amines, which can be used to crosslink and immobilize proteins and other molecules.
Amine-and-carboxyl (amino acid) compound that contains an internal disulfide bond; use with crosslinkers to modify functional groups on proteins and surfaces.
Amine-reactive compound to reversibly cap lysines and other primary amines with carboxyl groups; stable at pH 7 but hydrolyzes (decouples) at pH 3 to 4. CAS 616-02-4.
C2H4(NH2)2 (CAS 107-15-3) to polymerize or amine-modify carboxylate molecules using EDC (carbodiimide) crosslinker for use in a variety of applications.
Methyl methanethiosulfonate (CAS 2949-92-0); reversibly blocks cysteines (sulfhydryl groups) to facilitate study of enzyme activation and protein functions.
Short (4.1A), amine-reactive (NHS ester) sulfhydryl-addition reagent; creates stable (protected yet exposable) -SH group for protein crosslinking strategies.
NaOI4 (CAS 7790-28-5); to gently oxidize glycoprotein carbohydrate sugars to create reactive aldehydes (carbonyls) for crosslinking and immobilization.
Amine-reactive (NHS ester) compound to permanently block primary amines (e.g., protein lysine side chains) to prevent interactions or later conjugation.
2-Iminothiolane-HCl (CAS 4781-83-3); an amine-reactive thiolation reagent to cap protein primary amines with sulfhydryl groups for immediate crosslinking.
