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PRKDC
Gene Description
protein kinase, DNA-activated, catalytic polypeptide
Alternative Names
HYRC; p350; DNAPK; DNPK1; HYRC1; XRCC7
Molecular Weight
350 kDa
Summary
The PRKDC gene encodes the catalytic subunit of a nuclear DNAdependent serine/threonine protein kinase (DNA-PK). The second component is the autoimmune antigen Ku (MIM 152690), which is encoded by the G22P1 gene on chromosome 22q. On its own, the catalytic subunit of DNA-PK is inactive and relies on the G22P1 component to direct it to the DNA and trigger its kinase activity; PRKDC must be bound to DNA to express its catalytic properties.1
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