PRKDC

Gene Description
protein kinase, DNA-activated, catalytic polypeptide

Alternative Names
HYRC; p350; DNAPK; DNPK1; HYRC1; XRCC7

Molecular Weight
350 kDa

Summary
The PRKDC gene encodes the catalytic subunit of a nuclear DNAdependent serine/threonine protein kinase (DNA-PK). The second component is the autoimmune antigen Ku (MIM 152690), which is encoded by the G22P1 gene on chromosome 22q. On its own, the catalytic subunit of DNA-PK is inactive and relies on the G22P1 component to direct it to the DNA and trigger its kinase activity; PRKDC must be bound to DNA to express its catalytic properties.¹