Gene Description
Androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease)

Alternative Names
RP11-383C12.1, AIS, DHTR, HUMARA, KD, NR3C4, SBMA, SMAX1, TFM

Molecular Weight
120 kDa

Summary
AR contains 919 amino acids and has an approximate molecular weight of 98988. It contains glutamine (poly CAG), proline and glycine (GGC) homopolymeric sequences in the N terminal modulator region, a central bipartite (class II) zinc finger DNA binding domain and an hydrophobic C terminal ligand binding domain. It functions as a steroid-hormone activated transcription factor stimulating transcription of androgen responsive genes. It regulates of androgen action.¹