Gene Description
Polo-like kinase 1 (Drosophila)

Alternative Names
PLK; STPK13

Molecular Weight
67 kDa

Summary
The serine/threonine Polo-like kinases (PLK) are critical to the regulation of the G2/M cell cycle check point. Substrates include Cdc25C phosphatase, cyclin B, a cohesin subunit of the mitotic spindle, subunits of the anaphase promoting complex, and mammalian kinesin-like protein 1 MKLP-1 and other kinesin related motor proteins. These substrates demonstrate the multiple roles of Plk1 in promoting mitosis.¹