Gene Description
baculoviral IAP repeat-containing 4

Alternative Names
API3; ILP1; MIHA; XIAP; XLP2

Molecular Weight
53 kDa

Summary
The protein encoded by this gene is a member of a family of proteins which inhibit apoptosis through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2. Similar to API1, BIRC4 inhibits apoptosis induced by menadione, a potent inducer of free radicals, and ICE. BIRC4 also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7.¹