Gene Description
v-Ha-ras Harvey rat sarcoma viral oncogene homolog

Alternative Names
HRAS1; K-ras; N-ras; RASH1; c-bas/has

Molecular Weight
21 kDa

Summary
The ras genes give rise to a family of related GTP-binding proteins that exhibit potent transforming potential. Mutational activation of Ras proteins promotes oncogenesis by disturbing a multitude of cellular processes, such as gene expression, cell cycle progression and cell proliferation, as well as cell survival, and cell migration. Ras signalling pathways are well known for their involvement in tumour initiation, but less is known about their contribution to invasion and metastasis.¹