TCR beta F1 antibody for immunohistochemistry (IH) and other applications.

This Thermo Scientific Pierce monoclonal antibody enables measurement of human T cell receptor beta F1 in immunohistochemistry, immunoprecipitation and Western blotting. The mouse IgG1 antibody (clone 8A3) has been cited in several research papers involving the study of lymphoma. It is most often used for tissue staining and has been used to stain both frozen sections and paraffin-embedded tissue, but is also suitable for immunoprecipitation and flow cytometry. This antibody is typically supplied in PBS with preservative and carrier protein but can be supplied in preservative-free, carrier-free PBS for custom orders.

TCR1151 (clone 8A3) is specific for human TCR b chain constant region (TCRBC).

See info-sheet (PDF) in the ordering information table below for additional product-specific information.

Related TCR Antibody Products

• Human Pan TCR gamma delta Monoclonal Antibody (Product # TCR1061)
• Human TCR alpha F1 Monoclonal Antibody (Product # TCR1145)

References

1. Calaman, S.D., et al. (1993). Characterization of monoclonal antibodies specific for the V beta 3 family of the human T cell receptor generated using soluble TCR beta-chain. J. Immunol. Method. 164: 233.
2. Campana, D., et al. (1989). The expressions of T-cell receptor-associated proteins during T-cell ontogeny in man. J. Immunol. 142(1): 57-66.
3. Falini, B., et al. (1998). Distribution of T-cells bearing different forms of the T-cell receptor gamma/delta in normal and pathological human tissues. J. Immunol. 143(8): 2480-2488.
4. Henry, L., et al. (1989). Two distinct immunogenic epitopes on the alpha chain of human T-cell antigen receptor. Hybridoma. 8(6), 577.
5. Jacobs, M., et al. (1992). Increase in TCR gamma delta T lymphocytes in synovial from rheumatoid arthritis patients with active synovitis. J. Clin. Immunol. 12: 130-138.
6. Lohman, B.L., et al. (1995). Antiviral cytotoxic T lymphocytes in vaginal mucosa of simian immunodeficiency virus-infected rhesus macaques. J. Immunol. 155, 5855-5860.
7. Macon, W.R., et al. (1998). T-cell subset analysis of peripheral T-cell lymphocytes by paraffin section immunohistology and correlation of CD4/CD8 results with flow cytometry. Am. J. Clin. Pathol. 109, 610-617.
8. Puellmann, K., et al. (2006). A variable immunoreceptor in a subpopulation of human neutrophils. PNAS, 103(39): 14441-14446.
9. Streubel, B., et al. (2004). Lymphoma-specific genetic aberrations in microvascular endothelial cells in B-cell lymphomas. N. Eng. J. Med. 351: 250-259.
10. Taskinen, M., et al. (2004). Increased cell turnover, but no signs of increased T-cell infiltration or inflammatory cytokines in the duodenum of pediatric patients after allogeneic stem cell transplantation. Bone Marrow Transplantation. 34: 221-228.
11. Westernholm-Ormio, M., et al. (2003). Immunologic activity in the small intestinal mucosa of pediatric patients with type I diabetes. Diabetes. 52: 2287-2295.